Dream as the Creative Imagination in Mark Twain's the Mysterious Stranger Manuscripts

Englis

Intensive Cultural Resources Survey Of The Proposed Wurzbach Parkway Extension Project From Blanco Road To Wetmore Road, Bexar County, Texas

SWCA Environmental Consultants (SWCA) conducted an intensive cultural resources survey on behalf of the Texas Department of Transportation (TxDOT), of the proposed Wurzbach Parkway Extension Project in San Antonio, Texas. TxDOT proposes to extend the existing Wurzbach Parkway approximately 5.3 miles between Farm-to-Market Road (FM) 2696 (Blanco Road) and Wetmore Road. The undertaking involves the new construction of a four-lane divided roadway within an approximately 250-foot right-of-way (ROW) that is state-owned property. Overall, the Area of Potential Effects (APE) is 27,984 feet long, 250 feet wide, and maximally 10 feet deep. Additionally, the APE covers roughly 51.77 acres of permanent and temporary easements. SWCA’s investigations of the Wurzbach Parkway Extension Project APE included a background review, and an intensive pedestrian survey with shovel testing and backhoe trenching of selected areas within the APE. The background literature review determined that 21 surveys of varying magnitude have been conducted within or adjacent to the APE. These surveys are related to roadway construction or expansion, as well as park development. Fourteen archaeological sites have been documented within or adjacent to the APE and 44 additional archaeological sites have been previously recorded within 1 mile of it. The APE traverses a portion of the Walker Ranch National Register District, but the undertaking does not affect any contributing resources besides those that were previously mitigated by TxDOT in the 1990s. SWCA archaeologists conducted field investigations within the Wurzbach Parkway Extension Project APE between May 1 and June 21, 2007. The pedestrian survey established that the majority of the APE has been disturbed by previous residential, commercial, and dam construction. Of the 14 previously recorded sites within or immediately adjacent to the APE, seven were determined during the current survey not to extend into the APE (41BX181, 41BX183, 41BX194, 41BX203, 41BX209, 41BX222, and 41BX223). Two of the seven sites within the APE had been successfully mitigated through prior data recovery efforts (41BX184 and 41BX228), while landforms associated with site 41BX202 were found to have been completely destroyed. Current investigations included a reconnaissance survey of site 41BX949, shovel testing at site 41BX948, and backhoe trenching at site 41BX947. Right of entry was denied at two properties, including the Coker United Methodist Church, which precluded a revisit to 41BX1062. The portions of sites 41BX184, 4BX202, 41BX228, and 41BX949 that remain in the Wurzbach Parkway Extension Project APE are not considered eligible for inclusion to the National Register of Historic Places (NRHP) or for designation as a State Archeological Landmark (SAL); therefore, SWCA recommends no further work at these sites. Survey-level excavations at 41BX947 and 41BX948 revealed no cultural materials, temporally diagnostic artifacts, features, or intact buried deposits. Thus, 41BX947 and 41BX948 have little to no research value. As such, neither 41BX947 nor 41BX948 is considered significant or eligible for inclusion in the NRHP or for designation as an SAL. Based on the extent of previous investigations and the results of the current survey, SWCA recommends no additional archaeological investigations for 41BX184, 4BX202, 41BX228, 41BX947, 41BX948, 41BX949, and 41BX1062. Subsequent to the SWCA survey, TxDOT conducted an impact evaluation of the additional 51.77 acres of easements associated with the project. No cultural resources were documented as part of this effort. This TxDOT work was submitted with the SWCA draft report to the Texas Historical Commission (THC) who concurred with the findings in both reports. This report combines the results of both investigations into a final report to satisfy the Texas Antiquities Code (TAC) permit requirements. In accordance with Section 106, 36 Code of Federal Regulations (CFR) 800.4, SWCA and TxDOT have made a reasonable and good faith effort to identify archaeological historic properties within the APE. As no properties were identified that meet the criteria for listing on the NRHP according to 36 CFR 60.4 or for designation as an SAL according to 13 TAC 26.12, no archeological historic properties are affected and SWCA recommends no further work for the 5.3-mile Wurzbach Parkway Extension Project APE. Artifacts were collected as part of the undertaking and will be curated at the Texas Archeological Research Laboratory

Sharing the Power: Training Consumer Health Information Center Volunteers Online

Introduction Tutorial created through cooperative efforts of the WHIC manager, volunteer coordinator, two Health Sciences Librarians, a graduate student, and a graduate intern. 19 months of iterative development Goals Reduce time required train volunteers Prepare volunteers to provide health information to consumers Track learning through built-in self assessment tools Learning Objectives WHIC's mission and procedures Using information resources Guiding customers to appropriate resources When and where to refer information request

Archeological Significance Testing at 41BX17/271, the Granberg Site: A Multi-Component Site along the Salado Creek in Bexar County, Texas

The Center for Archaeological Research (CAR) of The University of Texas at San Antonio conducted archeological significance testing at 41BX17, the Granberg Site, from January to March 2006. The testing was conducted for the Texas Department of Transportation, Environmental Affairs Division (TxDOT-ENV). The Granberg Site sits on the eastern flood terrace of the Salado Creek south of Loop 410 in San Antonio, Bexar County, Texas. Planned road improvements including installation of a storm sewer line and a water main prompted the need to assess whether (1) cultural deposits including human remains still exist after previous testing and (2) if the deposits contribute to the site’s National Register of Historic Places eligibility. The archeological work was conducted under Texas Antiquities Permit No. 4010. Steve A. Tomka served as Principal Investigator and Jennifer Thompson served as Project Archeologist. Fieldwork included mechanical auger boring and backhoe trenching to determine the horizontal extent of the site boundaries within the median of Loop 410 eastbound. Sixteen 1-x-1-m units were excavated to determine the distribution and integrity of the cultural deposits and to locate any possible burials that may still exist at the site. Materials recovered included burned rock features, chipped stone artifacts, animal bone, snail and mussel shell and charred plant remains. The distribution of the artifacts, the geomorphic investigations, the radiocarbon assays, and temporally diagnostic artifacts indicate the presence of Middle and Late Archaic archeological materials with good stratigraphic integrity. The Granberg Site was determined to be ineligible for the National Register of Historic Places. Following the completion of eligibility testing efforts, the TxDOT directed the CAR to develop a research design linking the data recovered from the various excavations at the Granberg Site with research goals. The CAR developed the research design (Munoz et al. 2007) under Work Authorization No. 57513SA005 with Cynthia M. Munoz serving as Project Archeologist. At roughly the time of the research design implementation, the CAR was the recipient of a donation of a collection of commingled human skeletal remains recovered from the Granberg Site. These remains were recovered from 41BX17/271 in 1962 by Harvey Kohnitz, an avocational archeologist, without knowledge or permission from the Texas Highway Department. The remains were stored at the Kohnitz home until his son, Mark Kohnitz, donated them to the CAR in 2007. An osteological analysis was conducted at the CAR laboratory during February 2008 for TxDOT, under Work Authorization No. 57513SA005 Supplemental Work Authorization No. 4. The results of this analysis are reported in Appendix H of this report. The commingled remains will be curated the CAR and all required documents, including an inventory, will be submitted to the National Park Service National NAGPRA Program to fulfill all obligations pertaining to the NAGPRA laws. All artifacts collected during this project and all project-associated documentation are permanently curated at the CAR according to Texas Historical Commission guidelines

Design and analysis of low boom concepts at Langley Research Center

The objective of the sonic boom research in the current High Speed Research Program is to ultimately make possible overland supersonic flight by a high speed civil transport. To accomplish this objective, it is felt that results in four areas must demonstrate that such a vehicle would be acceptable by the general public, by the airframers, and by the airlines. It should be demonstrated: (1) that some waveform shape has the possibility of being acceptable to the general public; (2) that the atmosphere would not totally destroy such a waveform during propagation; (3) that a viable airplane could be built which produces such a waveform; and (4) that any performance penalty suffered by a low boom aircraft would be counteracted by the economic benefit of overland supersonic flight. The work being done at LaRC is in support of the third element listed above--the area of configuration design. The initial part of the paper will give a review of the theory being used for configuration designs and discuss two theory validation models which were built and tested within the past two years. Discussion of the wind tunnel and theoretical results (linear theory and higher order methods) and their implications for future designs will be included

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin